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During puberty, testosterone triggers the development of male secondary sexual characteristics, including the deepening of the voice, facial and body hair growth, and increased muscle mass

Interestingly this study also reported a positive association between genetically predicted IGF-1 concentrations and breast cancer risk however this was only in ER+ tumours (Murphy et al., 2020)

Kissen, R., Rossiter, J

GSTs are multifunctional enzymes that catalyze the conjugation of glutathione (GSH) to electrophilic compounds, including xenobiotics and reactive oxygen species (ROS), converting these into less toxic metabolites for excretion 49

This setup lets you strip away all the other biological noise and focus only on how the pituitary cells respond