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Supporting Dermal Papilla Cells Dermal papilla cells sit near the base of the follicle and help regulate hair formation, follicle size, and growth-cycle timing

Elevated intraocular pressure (IOP) in glaucoma or direct optic nerve injury triggers RGC apoptosis via mitochondrial (cytochrome c/caspase-9/caspase-3) and death receptor (Fas-FasL/caspase-8) pathways

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Conclusions: In this post hoc analysis, treatment with sebetralstat 600 mg ended progression of HAE attacks early, with a median of 19.8 min in KONFIDENT-S, which was consistent with results from the KONFIDENT trial (medians of 19.8 and 19.2 min for 300 mg and 600 mg sebetralstat, respectively)