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Free radicals, primarily generated by cellular metabolism, are highly reactive molecules with unpaired electrons [8]

Patients with conditions showing strong preclinical evidence and limited alternative treatment options may represent reasonable candidates following thorough informed consent discussions

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Importantly, tirzepatide carries a boxed warning for risk of thyroid C-cell tumors and is contraindicated in patients with a personal or family history of medullary thyroid carcinoma (MTC) or in patients with Multiple Endocrine Neoplasia syndrome type 2 (MEN2)