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53.1 Doseresponse relationships in relation to toxicity

Clinicians typically consider switching to maintenance when a patient has reached approximately 70 to 90 percent of their target weight loss, has maintained a stable weight for 4 to 6 weeks, and has established healthy habits over a 6- to 12-month period

Exploratory objectives To explore changes in brain functional activity and connectivity in addiction-related regions using fMRI, and to investigate potential associations between neural measures, nicotine dependence, and metabolic changes

Boutros M, Maron D

Its not a medication you pop casually it needs monitoring, especially early on