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Most gastrointestinal side effects are mild to moderate and tend to resolve on their own as your body builds a tolerance

Both GLP-1 and GIP activity can affect fluid balance, and dehydration amplifies nausea and constipation

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The vitamin is then picked up by a protein called intrinsic factor, which is produced by parietal cells in the stomach lining

Constipation patterns on tirzepatide show similar frequency to semaglutide, suggesting that the delayed transit mechanism affects the entire GI tract similarly regardless of whether one or two receptors are being activated