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The SEMALEAN study followed 106 adults with obesity (mean BMI 46, mean age 52, roughly half meeting sarcopenic obesity criteria at baseline) on max-dose semaglutide for 12 months, with DXA and handgrip dynamometry at baseline, seven months, and twelve months
Retatrutide benefits stem from its unique status as a "triple agonist." While popular drugs like Ozempic mimic one hormone (GLP-1) and Mounjaro mimics two (GLP-1 and GIP), Retatrutide introduces a third player: Glucagon
Switching between GLP-1 compounds allows your provider to test which pathway combination works best for your unique genetics and symptom profile
However, as the first generic GLP-1 on the market, it should offer a significantly lower prices at a time when similar products are tripling their price points to locations outside the US