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Beyond DHFR inhibition, MTX and the polyglutamate forms impede de novo purine synthesis and thymidylate synthase, intensifying the cytotoxic effects that affect cell proliferation and growth (Mohamed et al., 2019)

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Sleep, circadian rhythm, and mood Sleep disruption and mood disorders exist in a bidirectional relationship so tight that untangling cause from effect is often impossible

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FDA approves new treatment for hypoactive sexual desire disorder in premenopausal women

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Over the past year, pharmaceutical companies and healthcare providers accelerated efforts to position these medications

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