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NICE guidance acknowledges the role of GLP-1 receptor agonists like semaglutide as treatment options for type 2 diabetes when metformin alone provides insufficient glycaemic control, particularly in patients where weight loss would be beneficial

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In SURPASS-5[4], patients with type 2 diabetes achieved HbA1c reductions of -2.11% to -2.34% and weight loss from 5.4 kg at 5 mg to 10.5 kg at 15 mg over 40 weeks