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Some researchers have theorized that vitamin B12 shots for weight loss might boost energy and endurance when you exercise, but there is not currently enough evidence to back up this theory

This randomized clinical trial focuses on the potential benefits of GSH in alleviating oxidative stress, a major factor in the progression of diabetes and its complications, while also examining improvements in glycemic markers

Pratley RE, Gilbert M (2008) Targeting incretins in type 2 diabetes: role of GLP-1 receptor agonists and DPP-4 inhibitors

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This does not mean zero drug reaches CNS targets, but it does mean the fraction is likely small and the pharmacokinetic profile is poorly characterized for that route