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0.0% with placebo, and decreased appetite (19.0% and 18.2%) vs

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Because sitagliptin is substantially excreted by the kidney, and because aging can be associated with reduced renal function, renal function should be assessed more frequently in elderly patients [see Dosage and Administration (2.2), Warnings and Precautions (5.3)] Sitagliptin is excreted by the kidney, and sitagliptin exposure is increased in patients with renal impairment

In particular, they found that the activation of GLP-1R promoted the secretion of atrial natriuretic peptide (ANP) and lowered blood pressure