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Research reveals that senescent cells show upregulation of pro-apoptotic initiators PUMA and BIM while anti-apoptotic guardian BCL-2 is reduced, suggesting these cells are ready to undergo apoptosis but the execution is restrained by the FOXO4-p53 interaction
Study summary Zito PM, Raggio BS, Syed K
HIGHLIGHTS: Stable BPC-157, a novel anti-ulcer peptide (1) BPC-157: Healing in different tissues Tendon Healing (4) Bone healing BPC-157 & Neuroprotective effect Effect on Spinal Cord Injury Blood Pressure Tendon Healing (4) Bone healing Stable BPC-157 as anti-ulcer agent (1) Stable gastric pentadecapeptide BPC 157 is a novel anti-ulcer peptide, used in trials for the treatment of ulcerative colitis and now multiple sclerosis, lethal dose (dosage required to kill 1% of the test population, LD1) not reported
In senescent cells, FOXO4 sequesters p53, blocking this process and allowing zombie cells to survive and secrete harmful inflammatory signals known as the Senescence-Associated Secretory Phenotype (SASP)
