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Here, we review the therapeutic effects of GLP-1 on depression from a variety of perspectives and highlight the promising, beneficial roles of GLP-1 as the therapeutic regulator of impaired neurogenesis, neuroinflammation, imbalance of neurotransmitter secretion, and synaptic dysfunction in the depressive brain

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a baseline recording was taken for 1 minute before addition of 100 nM exendin-4 and further imaging for 10 minutes

The SELECT trial establishing semaglutides 20% reduction in major adverse cardiovascular events has converted GLP-1 receptor agonists from single-indication obesity drugs into foundational chronic disease therapeutics demanding continuous prescription renewal