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The most advanced of them, danuglipron, has demonstrated good efficacy in a twice-daily formulation, and we believe a once-daily formulation has the potential to have a competitive profile in the oral GLP-1 space," said Mikael Dolsten, MD., PhD., chief scientific officer & president, Pfizer Research and Development

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Overall, the ADJUNCT programme demonstrated dose-dependent improvements in HbA 1c , a decrease in the daily insulin dose and a reduction in body weight with liraglutide compared with placebo

The LEADER and SUSTAIN-6 trials, which followed diabetic patients for 37 years on GLP-1 therapy, documented reduced heart attacks and strokes without accumulation of serious toxicity

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