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A phase II clinical trial is currently evaluating the efficacy and tolerability of front-line AMG-479, a fully-human monoclonal antibody against the IGF-1R, in combination with carboplatin and paclitaxel in advanced stage, optimally-debulked epithelial ovarian, primary peritoneal, and fallopian tube cancer (TRIO-014)
These proposals are pitched as patient safety measures
According to statistics, there are currently approximately 50 million people living with AD worldwide, and this number is expected to increase to 152 million by 2050 as the population ages, making it a major challenge for global public health (Dissanayaka et al., 2024)
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