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SPOTLIGHT The astounding rise of semaglutide and whats next for weight-loss drugs Access options Access Nature and 54 other Nature Portfolio journals Get Nature+, our best-value online-access subscription $32.99 / 30 days cancel any time Subscribe to this journal Receive 52 print issues and online access $199.00 per year only $3.83 per issue Rent or buy this article Prices vary by article type from$1.95 to$39.95 Prices may be subject to local taxes which are calculated during checkout doi: This article is part of Nature Spotlight: Obesity, an editorially independent supplement

doi: 10.1038/s41598-019-47375-2 91 NgTSBrittonGJHillEVVerhagenJBurtonBRWraithDC

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