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Estradiol reduces oxidative damage and its consequent apoptotic process (205)

There are receptors for these hormones distributed across many tissues and their effects are thus pleiotropic

Severe gastroparesis (delayed gastric emptying) is a caution or contraindication for some GLP-1 medications, as these drugs further slow gastric emptying and may exacerbate symptoms

The safety profile was also indistinguishable, except for a higher rate of premature treatment discontinuations caused by gastrointestinal adverse events in elderly vs non-elderly patients

Different opinions among the reviewers were addressed through discussion until an agreement was achieved