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too much reactive oxygen and nitrogen production was a significant contributor to UC owing to a greater vulnerability to intestinal inflammation and injury brought on by defective normal oxidative defense systems (Mazzolin et al

This can be on the body but it can also be on the face and neck

However, continuous research and vigilant monitoring are essential to optimize their safe use [55] [56], particularly as these medications are used in broader populations for longer durations

Disagreements were resolved through a consensus after discussing reasons for discrepancy

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