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111 Furthermore, the hyperlactylation of IKAROS family zinc-finger 1 (Ikzf1) at lysine 164 downregulates the expression of interleukin-2 (IL-2) and interleukin-4 (IL-4) while simultaneously enhancing the expression of Toll-like receptor 4 (Tlr4) and Runt-related transcription factor 1 (Runx1)