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Future research will need to clarify the extent to which these mechanisms are translatable into clinical practice and what their long-term implications may be for the human population

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More serious but less common adverse effects observed in trials or associated with this drug class include: Increased heart rate , a class effect seen with GLP-1 receptor agonists [15] [12] Gallbladder disease , including gallstones (cholelithiasis), which has been associated with rapid weight loss and incretin-based therapies more broadly

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