The de novo thymidylate (dTMP) biosynthesis pathway involves three enzymes: dihydrofolate reductase (DHFR), serine hydroxymethyltransferase (SHMT), and thymidylate synthase (TYMS) ( Figure 3 )
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doi: 10.3390/ijms20153611 275 KotwasIMcGonigalABastien-ToniazzoMBartolomeiFMicoulaud-FranchiJA