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[13] [14] [15] [16] [17] Adverse events are most commonly gastrointestinal symptoms such as nausea and diarrhea, with relatively low rates of study discontinuation and infrequent serious adverse events reported during trials

However, the framing of this data matters

The presence of hybrid receptors is likely to be an important contributor to the lack of success in developing inhibitory monoclonal antibodies against the IGF1R in human clinical trials for cancer therapy 24

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