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PMC - Assessing the Immunogenicity Risk of Peptide-Related Impurities: Scientific review on immunogenicity risk of peptide impurities
We stated in the correction notice to the CY 2026 PFS proposed rule that we would use the MEI update based on historical data through the second quarter of 2025 to determine the final MEI percentage increase and the CY 2026 KX modifier threshold amounts in the CY 2026 PFS final rule
It may also be used to treat other conditions, such as pernicious anemia, vitamin B12 malabsorption, and certain types of nerve pain
Researchers should note that this body of evidence derives predominantly from animal models, and independent replication remains more limited than in some other research areas
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