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Thyroid hormone regulation and cholesterol metabolism are connected through sterol regulatory element-binding protein-2 (SREBP-2)

Novel cAMP binding protein-BP (CREBBP) mutation in a girl with Rubinstein-Taybi syndrome, GH deficiency, Arnold Chiari malformation and pituitary hypoplasia

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This has resulted in several investigators concluding that its effects are irreversible, since in tissue environments its effects can last many days to weeks (German et al 2015)

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