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Generation of patient-derived organoids Patient-derived tumour organoid (PDO) cultures were generated from a primary pancreatic adenocarcinoma tumour obtained from a Caucasian male patient (age 69) with Stage 3 cancer and no evidence of local or distant metastasis

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One strategy currently being evaluated in early-phase clinical trials focuses on mitochondrial glutaminase (GLS1), an enzyme responsible for converting glutamine to glutamate (e.g., CB-839 from Calithera Biosciences) 40

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Effect of orally administered glutathione on glutathione levels in some organs of rats: role of specific transporters