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Glutamine deprivation or inhibition of glutamine synthase in Caco-2 cells in culture significantly decreased the transepithelial electrical resistance (TER) and increased the paracellular permeability of the cell monolayer (52) and increased bacterial translocation (66)

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The medication acts on specific receptors in the brain's appetite centres, particularly in the hypothalamus, to increase feelings of fullness (satiety) and reduce hunger

These include epigastric pain syndrome, functional dysphagia, heartburn, reflux hypersensitivity, belching disorder, bloating/distention, centrally mediated abdominal pain, fecal incontinence, and others

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