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however, some potential scenarios where it might be considered (only within an individualised plan agreed with a clinician) include: As an adjunct to lifestyle measures in individuals with non-diabetic hyperglycaemia (prediabetes) who wish to try additional interventions In people with type 2 diabetes who cannot tolerate metformin and are exploring complementary approaches alongside other prescribed medications As part of a holistic approach in individuals already achieving good glycaemic control who wish to explore additional metabolic support Important caveats : Berberine should never replace prescribed diabetes medications without explicit guidance from your diabetes care team Berberine should not be used for type 1 diabetes, diabetic ketoacidosis, during pregnancy or breastfeeding Self-management with supplements can be risky

Jennifer Sargent was the primary editor on this article and managed its editorial process and peer review in collaboration with the rest of the editorial team

Biodegradation 10 , 6373 (1999)

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