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All participants received treatment for at least 52 weeks, with a maximum treatment duration of 104 weeks or until the study was completed to collect and evaluate major adverse cardiovascular events (MACE)

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It also appears to modulate the gastrointestinal side effects of GLP-1 activation, which may explain why tirzepatide is better tolerated despite being more potent

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Rotating sites helps prevent a condition called lipodystrophy , which involves the localized breakdown or buildup of fat under the skin