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A high extracellular glutamate concentration was one of the first xCT inhibitors described but a few years later, erastin (standing for eradicator of RAS and small T antigen-expressing cells) was identified by Stockwell's group in RAS-mutated cancer cell lines as inhibitor of xCT transport (42)

10.1186/s13073-017-0451-z 36 BenakisC.BreaD.CaballeroS.FaracoG.MooreJ.MurphyM.et al

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