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Red points correspond to the case when the set of 73 key reaction rates were varied according a homogenous random distribution between 0.1 and 100 their nominal value, and blue points represents the case when both permeability and mRNA induction rates were fixed to their nominal values, whereas the rest of the parameters were randomly varied as above.

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Pretreatment with schisantherin A provided neuroprotection against induced cytotoxicity, regulated the intracellular accumulation of reactive oxygen species and inhibited NO overproduction by reducing the overexpression of inducible nitric oxide synthase in cells [206]