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The exact cause of neuronal death in Parkinson's remains incompletely understood, but contributing factors include oxidative stress, mitochondrial dysfunction, neuroinflammation, and abnormal protein aggregation (particularly alpha-synuclein)

Additionally, gene ontology analysis detected accumulation of transcripts related to the three steps of protein synthesis (initiation, elongation, termination) in Gclc fl/fl MZB compared to Gclc fl/fl FoB (Supplementary Fig

GLP-1s are not currently recommended during breastfeeding

Mirrored AIs such as these might reflect convergent evolution driven by continued chromosomal instability and selection for gene dosage 30 , effects of varied selective pressures in distinct environments, or selective deletion of different subclonal mutations

PLoS ONE 7 , e40074 (2012)