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Tirzepatide which targets both GLP-1 and GIP receptors has shown even more dramatic early results: weight loss of 1020 kg and insulin dose reductions exceeding 30% in observational and phase 2 data, with improved CGM time in range

Semaglutide is the active ingredient in both Wegovy and Ozempic

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Taking extra doses increases the risk of serious adverse events including severe gastrointestinal distress, pancreatitis, and unpredictable blood sugar changes

Changes in bowel habit that represent a significant departure from an individual's normal pattern, particularly in those over 60 years or with family history of colorectal cancer, should be evaluated in accordance with NICE guideline NG12 on suspected cancer recognition and referral