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On tolerability, both compounds produced mild-to-moderate gastrointestinal adverse events (nausea, diarrhea, constipation, vomiting), typically during dose escalation

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Zebrowska and Borowiec, 2025)

Artemisinin and its derivatives can reduce DNA damage, oxidative stress, and inflammation, inhibit cell proliferation, promote apoptosis, and regulate the cell cycle through multiple pathways, such as the TLR/NF-B, Keap1/Nrf2, and PI3K/Akt signaling pathways, thereby exerting a therapeutic effect on lung cancer and pre-lung cancer diseases