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New biological entities are either in discovery and preclinical (three) or in Phase II (three), including HMI-115, a prolactin receptor monoclonal antibody and MT 2990, a monoclonal antibody targeting interleukin-33 to treat pain

A genetic susceptibility for aminoglycoside-induced hearing loss exists in patients that carry a mutated A1555G allele in the mitochondrial 12S ribosomal RNA [91]