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At the present level of our knowledge, it is safe to conclude that the orobuccal route can be used for treatment of hyperpigmentation with glutathione GSH at a dose of 10040050 mg per day for periods of between 10 and 12 weeks, depending upon indication, and it is hoped the treatment can be repeated to maintain effect

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The FDAs Pharmacy Compounding Advisory Committee will review whether to officially clear any of them for compounding under 503A at its July 23-24, 2026 meeting