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Under high glucose conditions, GLP-1 at 100 nM enhanced the expression of osteogenic markers (collagen type I ( COL1 ), osteocalcin ( OCN ), runt-related transcription factor 2 ( RUNX2 ) and activated the Wingless-type MMTV integration site family member ( Wnt )/-catenin pathway, known to play a key role in osteogenesis, as shown by Li et al

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The new 5-HT hypothesis of depression: cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression

these are harder to quantify in studies but matter tremendously