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Scientific Literature Review Several studies have investigated the side effects of semaglutide, including its potential impact on the heart

Others in its drug class like Wegovy, have also seen a surge in demand, one so high that the Food and Drug Administration has reported a national drug shortage for them

and Europe to approve and broadly adopt GLP-1 therapy, with Japanese prescribers known for their comfort with GLP-1 in T2DM management

For weight loss, FDA 2026 rules require a BMI of 30+, or 27+ with a health issue (like heart disease)

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