GLP-1s including semaglutides (Ozempic and Wegovy) and tirzepatides (Mounjaro and Zepbound) have "special effects on multi-systems of the body," Decotiis said
The evidence indicates that dulaglutide may modulate central neurocognitive pathways through both direct brain access and peripheral-to-central signaling mechanisms [70]
Exposure to 9-tetrahydrocannabinol impairs the differentiation of human monocyte-derived dendritic cells and their capacity for T cell activation
Importantly, these data suggest the possibility for no titration and once monthly dosing, which may result in a more convenient, more scalable, and better tolerated way to administer GLP-1 medicines. The randomized, placebo-controlled, double-blind Phase 1 trial was designed to evaluate the tolerability, pharmacokinetics, pharmacodynamics and efficacy of subcutaneous MET-097 in 125 healthy, non-diabetic, overweight or obese adult participants
Loyo and colleagues recently reviewed the United States Veterans Health Administration database, and identified 121,174 patients with T2DM and ischemic heart disease, cerebrovascular disease, or peripheral arterial disease who had been prescribed SGLT2is, GLP-1RAs, or their combination
