Colocalization of GLUT2 glucose transporter, sodium/glucose cotransporter, and gamma-glutamyl transpeptidase in rat kidney with double-peroxidase immunocytochemistry
doi:10.1542/peds.2015-4256
BMJ 348 , g2366 (2014)
Key Expert Opinions Sean Wharton, lead study author and medical director of the Wharton Medical Clinic, Canada, emphasized the clinical significance of the findings, stating that The STEP UP trial demonstrated that we can increase the dose of semaglutide and achieve greater weight loss than previously seen, and in line with semaglutide established safety profile
Introduction Polycystic ovary syndrome (PCOS) is a common endocrine disease, influencing approximately 515% of reproductive-age women (68), which could cause ratio imbalance of estrogen, insulin resistance, hyperinsulinemia, hyperandrogenemia, endometrial dysfunction, infertility, cardiovascular disease, and obesity (9)