Most cytokines and their receptors are expressed by neurons and glial cells throughout development, and several studies have revealed that cytokines play important roles in neurogenesis, synapse formation, and plasticity, including IL-1, IL-6, TNF-, TGF-1 and IFN 326,327,328,329,330,331 Cytokines activate several signal transduction pathways, including the Janus kinase-signal transducer and activation of transcription (JAK-STAT) and PI3K/AKT/mTOR pathways, which regulate numerous cellular responses
In the right hands, these therapies reveal how quickly the bodyand the braincan rebound once insulin signaling, inflammation, and energy balance are restored
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The key principle across all side effects is that gradual dose escalation reduces severity, and most side effects are transient
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