10.2174/1568026615666150915121633 Summary Keywords coronavirus, COVID-19, selenium, glutathione, glutathione peroxidase 1, protease, selenoprotein, thioredoxin reductase Citation Taylor EW and Radding W (2020) Understanding Selenium and Glutathione as Antiviral Factors in COVID-19: Does the Viral M pro Protease Target Host Selenoproteins and Glutathione Synthesis
Nelson DB, Niu J, Mitchell K, Sepesi B, Vaporciyan AA, Hofstetter WL , Walsh G, Swisher S, Roth J, Antonoff M, Mehran R, Rice DC
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This process results from disproportionate globin chain synthesis, where excess unpaired -globin chains aggregate inside erythroid precursors, causing oxidative damage, membrane instability, and the initiation of apoptotic pathways
However, despite advances in delivery systems such as lipid nanoparticles, polymers, viral/bacterial vectors, and exosomes, the efficiency of RNA-based therapeutics to specific organs or cell types is limited [81]