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Increasing the amount of USP13 in HEK-293T cells increased BMAL1 protein in a dose-dependent manner, supporting USP13s role in BMAL1 stabilization via directly modulating its ubiquitination (Gu et al., 2025)

Because both medications affect digestion and appetite signals, the most common side effects tend to be gastrointestinal, including nausea, vomiting, constipation, and stomach discomfort

The key is maintaining the same schedule daily, which helps regulate circadian rhythms and optimize hormonal patterns

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Thus, providing the suitability of the both models, and damaging regimens used, these arguments ( i.e