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In very high doses there is a potential for nausea and pain at the injection site

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If you wake at 6 PM, dosing at 8 PM captures the same receptor responsiveness window as a day-shift worker dosing at 8 AM

Taking it with a small meal (particularly one containing fat) may support absorption

Nonetheless, in recent years, SGLT2 inhibitors have shown benefits in atherosclerotic disease, HF, total mortality, CV mortality, and progression of chronic kidney disease