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These findings establish a mechanistic link between excessive CGA exposure, cellular iron deprivation, and mitochondrial dysfunction, providing a crucial scientific basis for defining its safe dosage window and understanding its potential hepatotoxic risk under conditions of overdose or highly concentrated exposure

This stress response was not limited to the liver but instead observed across multiple tissues from Gclc KO mice, including the kidney and colon (Fig

doi: 10.1681/asn.2009020146 196 GuidoCWhitaker-MenezesDLinZPestellRGHowellAZimmersTAet al

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Your intestines can only absorb limited amounts regardless of how much you consume