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The lack of interactions of P37 Cagri with RAMP 1 and 3 is consistent with the ability of Cagri to form high-affinity interactions with the CTR protomer alone (Fig

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Its primary distinction is its dual-pathway mechanism (VEGFR2 + NO) combined with its gastric stability making it the only compound in this group with demonstrated activity when administered orally in animal models, not just by injection

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