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The excellent antioxidant activity of quercetin is exerted primarily through effects on glutathione, enzyme and reactive oxygen species (ROS) activity and by regulating signal transduction pathways such as heme-related factor oxygenase 1/nuclear factor erythroid 2 (Nrf2), mitogen-activated protein kinase, toll-like receptor 4/phosphatidylinositol-3-kinase, and adenosine monophosphate 5-activated protein kinase

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