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10-14 The Diabetes Control and Complications Trial demonstrated a relationship between improved blood glucose control and increased risk of early worsening of DR, as well as between long-term risk reduction of DR with sustained blood glucose improvement

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[1] [5] While there is limited evidence that GLP-1 receptor activation may influence sodium excretion (natriuresis) in experimental settings, this has not translated to clinically significant urinary frequency in clinical trials or post-marketing surveillance