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Clinical trials demonstrate lower HbA1c, fasting plasma glucose, and body weight with once-weekly semaglutide injections

Background In the United States, the prevalence of obesity is rapidly increasing with 65% of adults and 17% of adolescents and children classified as being overweight or obese ( Behavioral intervention with lifestyle and dietary modification usually achieves modest weight loss ( 2 or a BMI 27kg/m 2 in the presence of comorbidities such as diabetes ( Bariatric surgery, sometimes referred to as metabolic surgery, is usually considered for patients who have a BMI 40 kg/m 2 or a BMI 35 kg/m 2 associated with comorbidities such as type 2 diabetes ( Observational and prospective studies have suggested that bariatric surgery is the most effective intervention for weight loss producing an average weight loss of 3035% that is maintained in ~60% of patients at 5 years (1)

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