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Obesity prevalence is highest in developed and Western nations, with the United States of America (US) demonstrating one of the highest obesity prevalence rates globally 42%

This dehydration risk is the primary concern prompting temporary metformin discontinuation

Using the Weil-Blakesley conchotome technique (Ekblom, 2017), one muscle sample (~50 mg) was snap frozen in liquid nitrogen for later analysis of the mitochondrial proteins

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