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Chen X, Zaro JL, Shen WC (2013) Fusion protein linkers: property, design and functionality

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IGF-LR3 (Insulin-like Growth Factor 1, Long Arg3) is a synthetic IGF-1 analogue carrying a 13-residue N-terminal extension and an arginine swap at position 3. Together these changes sharply lower affinity for IGF-binding proteins, lengthening functional half-life and improving receptor availability making it a workhorse in proliferation and anabolic-signalling research