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Participants were randomly assigned to receive either the higher 7.2 mg dose, the approved 2.4 mg dose, or a placebo for 72 weeks

In these cases, treatment focuses on pain management, often through over-the-counter pain relievers, and encouraging fluid intake to facilitate the stones passage

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There were no statistically significant differences between the cases and controls in age, sex, marital status, smoking status, history of hypertension or type 2 diabetes, total cholesterol and LDL-cholesterol